EDUCATIONAL COMMENTARYPLATELET
Platelet Refractoriness Definition and Determination When platelets are transfused the 1 hour post transfusion platelet count is expected to increase by 5 103 3to 10 10 /µL for each whole blood–derived platelet concentrate or by 20 103 to 60 103 /µL for
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The definition of refractoriness to platelet transfusions
The percentage agreement between common definitions of refractoriness was calculated based on these parameters As the maintenance of platelet counts above 20 x 10 9 /l is a relevant clinical goal for platelet support the values of the CI PI and REC which best corresponded to 1 and 20 h post transfusion counts of 20 x 10 9 /l were identified
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Refractoriness Article about Refractoriness by The Free
Refractoriness a short term decrease in the excitability of nervous or muscle tissue occurring immediately after the manifestation of action potential It can be detected by the stimulation of nerves and muscles by paired electrical impulses If the force of the first impulse is sufficient to produce action potential the response to the
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Assessing Platelet Refractoriness and the Appropriate Use
A formal and specific definition for platelet refractoriness using the CCI was outlined in the Trial to Reduce Alloimmunization to Platelets TRAP study 4 5 Platelet Refractoriness = A poor response to platelet transfusions on at least two separate sequential occasions using ABO identical platelet units that are less than 72 hours old with
Get PricePlatelet transfusion refractoriness how do I diagnose and
Platelet refractoriness is defined as a repeated suboptimal response to platelet transfusions with lower than expected posttransfusion count increments
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Guidance on Platelet Transfusion for Patients with Cancer
of platelet refractoriness should be excluded Alloimmunization is usually due to antibody against HLA antigens and only rarely to platelet specific antigens Patients with alloimmune refractory thrombocytopenia as defined previously † are best managed with platelet transfusions from histocompatible donors matched for HLA A and HLA B
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Platelet Transfusion Alloimmunization and Management of
Platelet Refractoriness Platelet refractoriness is a major complication in the management of hypoproliferative thrombocytopenic patients Platelet refractoriness may be due to immune or non immune causes The causes of non immune refractoriness include fever infection drugs splenomegaly and disseminated intravascular coagulation
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Platelet Refractoriness
Platelet Refractoriness Paolo Rebulla is Director of the Centre of Transfusion Medicine Cellular Therapy and Cryobiology at the Ospedale Maggiore Policlinico Mangiagalli Regina Elena Foundation Milan He was Chairman of the Biomedical Excellence for Safer
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recognition and management of platelet‑refractory
A critical unmet need is the development of a definition of an adequate response to platelet transfusion which would facilitate early recognition of platelet refractoriness in patients with PFDs who exhibit a normal platelet count Keywords platelet function disorder Glanzmann s thrombasthenia alloantibodies antiplatelet
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Refractoriness definition of refractoriness by Medical
Absolute platelet refractoriness associated with HLA antibodies A case report It can be seen that processing of refractory gold ores can yield low rates so they require implementation of extra stages such as roasting in order to eliminate the compounds that cause the refractoriness e g
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The definition of refractoriness to platelet transfusions
The percentage agreement between common definitions of refractoriness was calculated based on these parameters As the maintenance of platelet counts above 20 times 109/1 is a relevant clinical goal for platelet support the values of the CI PI and REC which best corresponded to 1‐ and 20‐h post‐transfusion counts of 20 times 109/1
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The definition of refractoriness to platelet transfusions
Definition of platelet refractoriness Post transfusion parameters The post transfusion platelet count was recorded 1 h after transfusion and again approximately 20 h after transfusion and the following additional parameters were calculated The platelet increment PI was defined as PI=Pz P where P I is the pre transfusion platelet count and
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tion of platelet concentrates from random donors as indicated by the lack of an ade quate post transfusion platelet count increment This condition goes under the term of platelet refractoriness 1 Although a certain level of theoretical consensus on the definition and management of platelet refractoriness existsas witnessed by a
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Platelet transfusion refractoriness how do I diagnose and
Platelet refractoriness continues to be a problem for thrombocytopenic patients because the risk of a major spontaneous or life threatening bleed significantly increases when platelet counts drop below 10 109/L The majority of patients have nonimmune causes driving the refractoriness such as bleeding medications or diffuse intravascular coagulation however this article is dedicated to
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Luminex as a diagnostic tool for platelet refractoriness
Definition of refractoriness „inadequate increase of platelet count post transfusion or „two consecutive 1 h post transfusion CCI < 7 5x109/l utilizing ABO identical platelet concentrates platelet concentrates <72h of collection
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EDUCATIONAL COMMENTARYPLATELET
Platelets are a critical component for maintaining hemostasis in patients who are actively bleeding and those with low number of platelets or with non functional platelets When a blood vessel is injured platelets adhere to the exposed collagen forming the primary platelet plug Platelets then aggregate at the injured site secreting various substances that promote vasoconstriction clot
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Immune Mechanisms of Platelet RefractorinessF
Multiple platelet transfusions may prove ineffective in approximately 40 of patients treated for bone marrow aplasia This condition is known as platelet refractoriness and is diagnosed by evaluating the corrected count increment following platelet transfusion
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American Red Cross HLA Laboratories Playing with Matches
Platelet Refractoriness A widely accepted definition of refractoriness is when two consecutive platelet transfusions lead to 1 hour post transfusion corrected count increments CCI of less than 5000 platelets x m2 per µL We recommend ABO identical
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HLA Mediated Platelet Refractoriness American Journal of
Platelet refractoriness can be attributed to nonimmune or immune causes Notably nonimmune causes comprise the largest proportion Immune mediated platelet refractoriness is indicated by a 1 hour CCI of less than 5 10 9 /L on two sequential occasions 6 HLA antibody testing and/or HLA typing can then be initiated
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Platelet Refractoriness AACC
However when a patient repeatedly does not respond adequately to their platelet transfusions they are defined as being refractory to platelets and in these cases an
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Thrombocytopenia is closely related to bleeding episodes in patients following HSCT 2 3 If platelet refractoriness is associated with GI bleeding routine hemostatic interventions may not help 11 Most patients in our case series remained dependent on platelet transfusion five patients became platelet transfusion refractoriness which would contribute to the failure of the hemostatic therapy
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Platelet Refractoriness
Platelet Refractoriness Paolo Rebulla is Director of the Centre of Transfusion Medicine Cellular Therapy and Cryobiology at the Ospedale Maggiore Policlinico Mangiagalli Regina Elena Foundation Milan He was Chairman of the Biomedical Excellence for Safer
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PLATELET REFRACTORNINESS Shan Yuan MD Updated
I Definition of refractoriness Refractory= failure to achieve an acceptable increment in platelet count following platelet transfusion at least on two occasions Platelet count must be measured within one hour after transfusion
Get PricePlatelet transfusion refractorinessHod2008British
Definition of platelet refractoriness Platelet refractoriness can be simply defined as a post transfusion platelet increment that is less than expected The difficulty in making this diagnosis arises in the specifics with a lack of agreement regarding the precise definition Phekoo et al 1997
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CCI Platelet Refractoriness iheartpathology
Platelet refractoriness noun The failure to achieve a desired increase in the platelet count following the administration of a unit of platelets on 2 separate occasions Generally speaking the platelet count is expected to increase 50 000/uL at 10 60 min and 40 000/uL at 18 24 h after transfusion of 1 unit of platelets using apheresis
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Platelet RefractorinesstouchONCOLOGY
The definition of refractoriness to platelet transfusions Transfusion Med 19922 35–41 Rebulla P Formulae for the detection of platelet refractoriness Transfusion Med 19933 91–3 Doughty HA Murphy MF Metcalfe P et al Relative importance of immune and non immune causes of platelet refractoriness Vox Sang 199466 200–205
Get PricePathology OutlinesPlatelet antibodies
Definition general Either autoimmune idiopathic thrombocytopenic purpura alloimmune neonatal alloimmune thrombocytopenia post transfusion purpura platelet transfusion refractoriness or heparin induced These tests must be ordered and interpreted cautiously considering the clinical presentation Blood 199789 1112
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Pathology OutlinesPlatelet refractoriness
Definition general Platelet refractoriness is the inability to get an adequate increase in platelet count after transfusion Arch Pathol Lab Med 409 Haematologica 200590 247 Immune causes antiplatelet or anti HLA antibodies after multiple exposures from transfusion pregnancy or transplantation Transfusion 200545 761
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Guidance on Platelet Transfusion for Patients with Cancer
of platelet refractoriness should be excluded Alloimmunization is usually due to antibody against HLA antigens and only rarely to platelet specific antigens Patients with alloimmune refractory thrombocytopenia as defined previously † are best managed with platelet transfusions from histocompatible donors matched for HLA A and HLA B
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Platelet transfusion Alloimmunization and refractoriness
Platelet refractoriness remains a clinical challenge and it is associated with worse clinical outcomes It is generally under recognised by clinicians with some studies suggesting that from 27 up to 44 of patients have unsatisfactory responses to platelet transfusions Although there are some mathematical formulas that clinicians can use 62 63 a diagnosis of refractoriness can most
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Formulae for the definition of refractoriness to platelet
Formulae for the definition of refractoriness to platelet transfusion Formulae for the definition of refractoriness to platelet transfusion Rebulla P 00 00 00 SIR Bishop et al 1992 reported the results of an elegant study aimed at examining the agreement between different formulae currently used to determine the â success or failureâ of platelet transfusion and in turn to
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Platelet Refractoriness in HemOnc PatientsA
Platelet Refractoriness Platelet refractoriness is defined as two consecutive platelet transfusions with 24 hr corrected count increments below 5x10 9 /L Up to 35 of hematology oncology patients who depend on platelet transfusion support become refractory to platelets during their treatment One possible cause of platelet refractoriness is
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Platelet refractorinesspractical approaches and ongoing
Definition Platelet refractoriness can represent a significant clinical problem that complicates provision of platelet transfusions and which may be associated with adverse clinical outcomes and increased health care costs
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Platelet Refractoriness The Basics
Platelet refractoriness A patient is refractory to platelet transfusions if the patient s circulating platelet levels consistently fail to increase by at least 10k/µliter after transfusion of an appropriate dose of platelets Clinical implications
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